Lysyl Oxidase Activity Is Required for Ordered Collagen Fibrillogenesis by Tendon Cells*
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چکیده
منابع مشابه
Development of tendon structure and function: regulation of collagen fibrillogenesis.
In the tendon, the development of mature mechanical properties is dependent on the assembly of a tendon-specific extracellular matrix. This matrix is synthesized by the tendon fibroblasts and composed of collagen fibrils organized as fibers, as well as fibril-associated collagenous and non-collagenous proteins. All of these components are integrated, during development and growth, to form a fun...
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Lysyl oxidase catalyzes the formation of crosslinking aldehydes in collagen and elastin. This report demonstrates that the enzyme has high activity with collagen precipitated as native fibrils, an apparent K(m) of 0.95 muM, and low activity toward either soluble forms such as denatured collagen, isolated alpha chain, or isolated alpha1-CBl peptide, or precipitated collagen fibrils after pepsin ...
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Lysyl oxidase (LOX) is an enzyme responsible for the cross-linking of collagen and elastin both in vitro and in vivo. The unique functions of the individual members of this multigene family have been difficult to ascertain because of highly conserved catalytic domains and overlapping tissue expression patterns. To address this problem of functional and structural redundancy and to determine the...
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Lysyl oxidase (LOX) plays a crucial role in the maintenance of extracellular matrix stability and could participate in vascular remodelling associated with cardiovascular diseases. Evidence from in vitro and in vivo studies shows that LOX downregulation is associated with the endothelial dysfunction characteristic of earlier stages of the atherosclerotic process. Conversely, upregulation of thi...
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Lysyl oxidase (LOX) serves an important role in remodeling the extracellular matrix and angiogenesis in various types of cancer; however, whether LOX is involved in the pathogenesis of rheumatoid arthritis remains unknown. In order to investigate this in the present study, β‑aminopropionitrile, an inhibitor of LOX, was injected intraperitoneally into rats with type II collagen‑induced arthritis...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2015
ISSN: 0021-9258
DOI: 10.1074/jbc.m115.641670